About GCNI

Our People

Biography

Phil studied medicine at The Chinese University of Hong Kong (CUHK) under the Global Physician-leadership Stream. Basic and translational genomics and epigenetics have been his long term interest. After graduation, he pursued doctoral studies (DPhil) at the Ludwig Institute for Cancer Research, University of Oxford, during which he studied cancer DNA methylation and its utility as a circulatory cell-free DNA biomarker. Phil’s major contribution was proposing a novel statistical framework to account for the variable cell type content in patient samples, which allowed him to define molecular signatures of interest using bulk sequencing samples, and subsequently detecting the signals in cell-free DNA. He has now returned to CUHK under the Neurology division as a Clinical Lecturer to continue his clinical training and passion in translational research. His expertise includes various DNA and RNA sequencing assays, as well as exploratory and statistical analysis of multi-omics and multi-modal data types.

Phil XIE

Clinical Lecturer, Department of Medicine and Therapeutics

Research Interests

  • neuroepigenetics in human biology and diseases
  • genomic medicine and interpretation of clinical variants
  • liquid biopsy in neurovascular pathologies
  • method development and sequencing assays

Awards

  • Croucher Foundation Scholarships, Croucher Foundation
  • NDM Prize Studentships, University of Oxford
  • Mabel Churn Scholarship, CUHK
  • Hong Kong Scholarship for Excellence Scheme, HKSAR

Selected publications

  1. T. M. Carroll, J. A. Chadwick, R. P. Owen, . . ., P. F. Xie, . . . et al., “Tumor monocyte content predicts immunochemotherapy outcomes in esophageal adenocarcinoma,Cancer Cell, vol. 41, no. 7, 1222–1241.e7, Jul. 2023, issn: 1878-3686.  doi: 10.1016/j.ccell.2023.06.006.
  2. I. A. Roundtree, G.-Z. Luo, Z. Zhang, . . ., P. Xie, . . . et al., “YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs,eLife, vol. 6, N. J. Proudfoot, Ed., e31311, Oct. 2017, issn: 2050-084X. doi: 10.7554/eLife.31311.
  3. W. Si, P. F. Xie, K. Y. Ma, . . . et al., “Antioxidant Activity of Sesamin in Canola Oil,Journal of the American Oil Chemists’ Society, vol. 90, no. 4, pp. 511–516, 2013, issn: 1558-9331. doi: 10.1007/s11746-012-2198-4.
  4. H. S. Fuchs, S. A. James, T. M. Carroll, P. F. Xie, . . . et al., “Abstract CT208: High tumor monocyte content predicts long-term survival for patients with operable oesophageal cancer treated with neoadjuvant immunochemotherapy in the LUD2015-005 trial,” in Cancer Research, vol. 84, Apr. 2024, CT208. doi: 10.1158/1538-7445.AM2024-CT208.
  5. P. Xie, M. Innoue, P. Siejka-Zielińska, . . . et al., “Abstract 2489: A cell-free DNA methylation biomarker outperforms irRECIST in predicting treatment outcome,” in Cancer Research, vol. 84, Mar. 2024, p. 2489.  doi: 10.1158/1538-7445.AM2024-2489.