Our People

Associate Professor, School of Life Sciences

• Brain metabolic changes in Alzheimer’s disease and related dementia
• Neuronal senescence in brain aging and diseases
• Endocrine and brain health crosstalk

• Awardee, Faculty Young Researcher Award, Faculty of Science, The Chinese University of Hong Kong, Hong Kong, 02/2025.
• Awardee, International Health Policy Fellowship, The National Academy of Medicine (NAM), USA, 07/2023-12/2025.
• Awardee, Faculty Exemplary Teaching Award, Faculty of Science, The Chinese University of Hong Kong, Hong Kong. 04/2022.
• Awardee, Excellent Young Scientists Fund (Hong Kong and Macau), National Natural Science Foundation of China, China. 09/2021.
• Awardee, Young Investigator Award, CUHK East Meets West Symposium 2019, Hong Kong. 09/2019.

1. Jacquelyne Ka-Li Sun, Amy Zexuan Peng, Ronald P. Hart, Karl Herrup, Deng WU, Genper Chi-Ngai Wong, Kim Hei-Man Chow. (2025) Perimenopausal state oestradiol to progesterone imbalance drives Alzheimer’s risk via ERRα dysregulation and energy dyshomeostasis. Nature Communications. 2025 Nov 22;16(1):11546. doi: 10.1038/s41467-025-66726-4
   • CUHK press release
2. Jacquelyne Ka-Li Sun, Ronald P. Hart, Karl Herrup, Amy Zexuan Peng, Genper Chi-Ngai Wong, Deng WU, Kin-Ming Kwan, Kim Hei-Man Chow. (2025) Alpha-ketoglutarate mitigates insulin resistance and metabolic inflexibility in a mouse model of Ataxia-Telangiectasia. Nature Communications. 2025 Oct 21;16(1):9312. doi: 10.1038/s41467-025-64360-8
   • CUHK press release
3. Deng Wu, Jacquelyne Ka Li Sun, Kim Hei-Man Chow. (2024) Neuronal cell cycle re-entry events in the aging brain are more prevalent in neurodegeneration and lead to cellular senescence. PLOS Biology. 2024 Apr 23;22(4):e3002559. doi: 10.1371/journal.pbio.3002559
   • PLOS Biology editors’ top picks for 2024
   • CUHK press release
4. Deng Wu, Xiaoman Bi, Kim Hei-Man Chow. (2024) Identification of female-enriched and disease-associated microglia (FDAMic) contributes to sexual dimorphism in late-onset Alzheimer’s disease. Journal of Neuroinflammation. 2024 Jan 4;21(1):1. doi: 10.1186/s12974-023-02987-4
5. Deng Wu, Xiaoman Bi, Peihu Li, Dahua Xu, Jianmin Qiu, Kongning Li, Shaojiang Zheng, Kim Hei-Man Chow. (2023) Enhanced insulin-regulated phagocytic activities support extreme health span and longevity in multiple populations. Aging Cell 2023 Mar 8;e13810. doi: 10.1111/acel.13810
   • CUHK press release
6. Jacquelyne Ka-Li Sun, Deng Wu, Genper Chi-Ngai Wong, Tsun-Ming Lau, Meigui Yang, Ronald P Hart, Kin-Ming Kwan, Ho-Yin Edwin Chan, Hei-Man Chow. (2023) Chronic alcohol metabolism results in DNA repair infidelity and cell-cycle-induced senescence in neurons. Aging Cell 2023 Feb; 22(2):e13772. doi: 10.1111/acel.13772
7. Hei-Man Chow, Jacquelyne Ka-Li Sun, Ronald P Hart, Kenneth King-Yip Cheng, Clara HL Hung, Tsun-Ming Lau, Kin-Ming Kwan. (2021) Low-density lipoprotein receptor-related protein 6 cell surface availability regulates fuel metabolism in astrocytes. Advanced Science. 2021 Aug;8(16):e2004993. doi: 10.1002/advs.202004993
   • CUHK press release
8. Hei-Man Chow, Meng Shi, Aifang Cheng, Yuehong Gao, Guimiao Chen, Xuan Song, Raphaella Wai Lam So, Jie Zhang, Karl Herrup. (2019) Age-related hyperinsulinemia leads to insulin resistance in neurons and cell-cycle-induced senescence. Nature Neuroscience. 2019 Nov;22(11):1806-1819. doi: 10.1038/s41593-019-0505-1
   • F1000 Prime (2-Star article)
9. Hei-Man Chow, Aifang Cheng, Xuan Song, Mavis R Swerdel, Ronald P Hart, Karl Herrup. (2019) ATM is activated by ATP depletion and modulates mitochondrial function through NRF1. Journal of Cell Biology. 2019 Mar 4;218(3):909-928. doi: 10.1083/jcb.201806197
   • Journal spotlight and commentary article
10. Hei-Man Chow, Karl Herrup. (2015) Genomic integrity and the ageing brain. Nature Reviews Neuroscience. 2015 Nov;16(11):672-84. doi: 10.1038/nrn4020