Our People

Associate Professor, School of Life Sciences

• Brain metabolic changes in Alzheimer’s disease and related dementia
• Neuronal senescence in brain aging and diseases
• Endocrine and brain health crosstalk

• Awardee, Faculty Young Researcher Award, Faculty of Science, The Chinese University of Hong Kong, Hong Kong, 02/2025.
• Awardee, International Health Policy Fellowship, The National Academy of Medicine (NAM), USA, 07/2023-12/2025.
• Awardee, Faculty Exemplary Teaching Award, Faculty of Science, The Chinese University of Hong Kong, Hong Kong. 04/2022.
• Awardee, Excellent Young Scientists Fund (Hong Kong and Macau), National Natural Science Foundation of China, China. 09/2021.
• Awardee, Young Investigator Award, CUHK East Meets West Symposium 2019, Hong Kong. 09/2019.

1. Perimenopausal state oestradiol to progesterone imbalance drives Alzheimer’s risk via ERRα dysregulation and energy dyshomeostasis.
   Jacquelyne Ka-Li Sun, Amy Zexuan Peng, Ronald P. Hart, Karl Herrup, Deng WU, Genper Chi-Ngai Wong, Kim Hei-Man Chow.
   Nature Communications. 2025 Nov 22;16(1):11546
2. Alpha-ketoglutarate mitigates insulin resistance and metabolic inflexibility in a mouse model of Ataxia-Telangiectasia.
   Jacquelyne Ka-Li Sun, Ronald P. Hart, Karl Herrup, Amy Zexuan Peng, Genper Chi-Ngai Wong, Deng WU, Kin-Ming Kwan, Kim Hei-Man Chow.
   Nature Communications. 2025 Oct 21;16(1):9312
3. Neuronal cell cycle reentry events in the aging brain are more prevalent in neurodegeneration and lead to cellular senescence.
   Deng Wu, Jacquelyne Ka Li Sun, Kim Hei-Man Chow.
   PLOS Biology. 2024 Apr 23;22(4):e3002559
4. Identification of female-enriched and disease-associated microglia (FDAMic) contributes to sexual dimorphism in late-onset Alzheimer’s disease.
   Deng Wu, Xiaoman Bi, Kim Hei-Man Chow.
   Journal of Neuroinflammation. 2024 Jan 4;21(1):1
5. Enhanced insulin‐regulated phagocytic activities support extreme health span and longevity in multiple populations.
   Deng Wu, Xiaoman Bi, Peihu Li, Dahua Xu, Jianmin Qiu, Kongning Li, Shaojiang Zheng, Kim Hei-Man Chow.
   Aging Cell. 2023 Mar 8;22(5):e13810
6. Chronic alcohol metabolism results in DNA repair infidelity and cell cycle‐induced senescence in neurons.
   Jacquelyne Ka-Li Sun, Deng Wu, Genper Chi-Ngai Wong, Tsun-Ming Lau, Meigui Yang, Ronald P Hart, Kin-Ming Kwan, Ho-Yin Edwin Chan, Kim Hei-Man Chow.
   Aging Cell. 2023 Jan 23;22(2):e13772
7. Low‐Density Lipoprotein Receptor‐Related Protein 6 Cell Surface Availability Regulates Fuel Metabolism in Astrocytes.
   Kim Hei-Man Chow, Jacquelyne Ka-Li Sun, Ronald P Hart, Kenneth King-Yip Cheng, Clara HL Hung, Tsun-Ming Lau, Kin-Ming Kwan.
   Advanced Science. 2021 Jun 27;8(16):2004993
8. Age-related hyperinsulinemia leads to insulin resistance in neurons and cell-cycle-induced senescence.
   Kim Hei-Man Chow, Meng Shi, Aifang Cheng, Yuehong Gao, Guimiao Chen, Xuan Song, Raphaella Wai Lam So, Jie Zhang, Karl Herrup.
   Nature Neuroscience. 2019 Oct 21;22(11):1806-1819
9. ATM is activated by ATP depletion and modulates mitochondrial function through NRF1.
   Kim Hei-Man Chow, Aifang Cheng, Xuan Song, Mavis R Swerdel, Ronald P Hart, Karl Herrup.
   Journal of Cell Biology. 2019 Jan 14;218(3):909-928
10. Genomic integrity and the ageing brain.
    Kim Hei-Man Chow, Karl Herrup.
    Nature Reviews Neuroscience. 2015 Oct 14;16(11):672-684